Search results for "Cornelia de Lange"

showing 7 items of 7 documents

Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood.

2021

Postzygotic mosaicism (PZM) in NIPBL is a strong source of causality for Cornelia de Lange syndrome (CdLS) that can have major clinical implications. Here, we further delineate the role of somatic mosaicism in CdLS by describing a series of 11 unreported patients with mosaic disease-causing variants in NIPBL and performing a retrospective cohort study from a Spanish CdLS diagnostic center. By reviewing the literature and combining our findings with previously published data, we demonstrate a negative selection against somatic deleterious NIPBL variants in blood. Furthermore, the analysis of all reported cases indicates an unusual high prevalence of mosaicism in CdLS, occurring in 13.1% of p…

AdultMaleCornelia de Lange SyndromeAdolescent Adult Cell Cycle Proteins Child Child Preschool Comparative Genomic Hybridization De Lange Syndrome Female Gene Deletion High-Throughput Nucleotide Sequencing Humans Male Middle Aged Mosaicism Mutation Missense Phenotype Retrospective Studies Spain Young AdultAdolescentSomatic cellScienceGenetic counselingMedizinMutation MissenseDiseasesCell Cycle ProteinsBiologyPaediatric researchGermlineArticle03 medical and health sciencesNegative selectionYoung AdultMedical researchDe Lange SyndromeGenetics researchmedicineMissense mutationHumansClinical significanceChild030304 developmental biologyRetrospective StudiesGenetics0303 health sciencesComparative Genomic HybridizationMultidisciplinaryMosaicismQ030305 genetics & heredityRHigh-Throughput Nucleotide SequencingNIPBLMiddle Agedmedicine.diseasePhenotypeSettore MED/03 - Genetica MedicaSpainChild PreschoolMedicineFemaleGene Deletion
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Behavioral phenotype and autism spectrum disorders in Cornelia de Lange syndrome

2015

Cornelia de Lange syndrome (CdLS) is a congenital disorder characterized by distinctive facial features, growth retardation, limb abnormalities, intellectual disability, and behavioral problems. Cornelia de Lange syndrome is associated with abnormalities on chromosomes 5, 10 and X. Heterozygous point mutations in three genes (<em>NIPBL</em>, <em>SMC3</em> and <em>SMC1A</em>), are responsible for approximately 50-60% of CdLS cases. CdLS is characterized by autistic features, notably excessive repetitive behaviors and expressive language deficits. The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in CdLS. However, the pro…

Behavioral phenotypePediatricsmedicine.medical_specialtyCornelia de Lange SyndromeAutism; Behavioral phenotype; Cornelia de Lange syndrome; Psychiatry and Mental Healthlcsh:RC435-571Autismlcsh:MedicineCase ReportSMC1Alcsh:PsychiatryIntellectual disabilitymedicinePsychiatrylcsh:RNIPBLmedicine.diseasePhenotypeCornelia de Lange syndromeSettore MED/39 - Neuropsichiatria InfantilePsychiatry and Mental healthAutism spectrum disorderAutismPsychologyCongenital disorderMental Illness
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Neuromuscular disorders and non compaction

2010

Abstract For neurological disorders we consider every possible affection of the central nervous system or neuro-muscular junction, in the presence of complex syndromes as well, such as Cornelia De Lange syndrome or any other. In our experience the incidence of neurological or neuromuscular envolment in patients affected by noncompaction is low. An incidence of comorbidities higher than 20% is not recorded in any centre, in published experiences. Data of the Vienna group could be likely influenced by selection bias (second level centre) or territorial genetic factors, or could depend on higher sensibility of used diagnostic techniques of neurological disease. But, if it was so, in our opinio…

Selection biasPediatricsmedicine.medical_specialtyCornelia de Lange Syndromebusiness.industryIncidence (epidemiology)media_common.quotation_subjectCognitionDiseasemedicine.diseasemedicineIn patientCardiology and Cardiovascular MedicinebusinessPractical implicationsmedia_commonInternational Journal of Cardiology
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Mealtime behaviour disorders in Cornelia de Lange syndrome

2016

Rationale and objectives: Cornelia de Lange syndrome (CdLS) is a multisystem congenital syndrome at variable expressivity. Children with CdLS can exhibit a range of “autistic-like” behaviours. Only a few studies have investigated the presence of eating "autistic-like" behaviors in individuals with CdLS. The aim of this study is investigating eating disorders and food selectivity among children affected by CdLS compared to autistic spectrum disorder (ASD) and typical developing (TD) children. Materials and methods: 16 children affected by CDLs (10 M, mean age 5.12±1.98 years) were compared to 35 ASD children (20 M, mean age 4.94±1.72 years) and 77 TD children (41 M, mean age 4.78±2.06 years)…

Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazionebehaviour disorderCornelia de Lange syndromeSettore MED/39 - Neuropsichiatria Infantile
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El síndrome de Langer Giedion, de Cornelia de Lange y comorbilidad: una revisión bibliográfica

2015

Los Síndromes de Langer Giedion (LGS) y el de Cornelia de (CdLS) son síndromes congénitos raros, causados por una alteración cromosómica y pueden aparecer comórbidos. Ambos se caracterizan por anormalidades esqueléticas, retraso del crecimiento, rasgos faciales distintivos y específicos, y discapacidad intelectual en severidad variable. Se presenta una revisión bibliográfica, de artículos publicados en el periodo 2010-2015, sobre ambos síndromes y su comorbilidad. Se han seleccionado para su análisis 33 artículos, con el objetivo de determinar el estado de la literatura científica actual. En los resultados se observa cómo las publicaciones relacionadas con estos síndromes pertenecen en su m…

comorbilidadfenotipofenotipo conductualSíndrome Cornelia de LangeSíndrome Langer Giedion
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Nuova mutazione del gene NIPBL in paziente affetto da Sindrome di Cornelia de Lange: report clinico e correlazione genotipo-fenotipo

2016

gene NIPBL, Sindrome Cornelia de Lange

gene NIPBL Sindrome Cornelia de LangeSettore MED/38 - Pediatria Generale E Specialistica
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Cornelia de Lange syndrome: A case report

2007

Cornelia de Lange is a genetic syndrome which affects between 1/10.000 and 1/60.000 neonates, but its genetic bases are still not clear. Its principal clinical characteristics are the delay in growth and development, hirsute, structural anomalies in the limbs and distinctive facial characteristic. Dental problems are frequent and include: ogival palate, micrognathia, dental malalignment, delayed teething, microdontic teeth, periodontal disease and dental erosion produced by gastric reflux. Discussed is the case of a 29 year old patient affected by the syndrome in question, which presents the principal clinical characteristics. The patient?s general state of health is acceptable, without car…

stomatognathic diseasesspecial patientsCornelia de Langestomatognathic systemodontological treatmentUNESCO::CIENCIAS MÉDICAS:CIENCIAS MÉDICAS [UNESCO]
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